Do not share your Ozempic^® pen with other
people, even if the needle has been changed.
You may give other people a serious infection,
or get a serious infection from them.

What is the most important information I
should know about Ozempic^®?

Ozempic^® may cause serious side effects, including:

•Possible thyroid tumors, including cancer. Tell
your health care provider if you get a lump or
swelling in your neck, hoarseness, trouble
swallowing, or shortness of breath. These may be
symptoms of thyroid cancer. In studies with
rodents, Ozempic^® and medicines that work like
Ozempic^® caused thyroid tumors, including
thyroid cancer. It is not known if Ozempic^® will
cause thyroid tumors or a type of thyroid cancer
called medullary thyroid carcinoma (MTC) in
people.

•Do not use Ozempic^® if you or any of your family
have ever had MTC, or if you have an endocrine
system condition called Multiple Endocrine
Neoplasia syndrome type 2 (MEN 2).

What is Ozempic^®?

Ozempic^® (semaglutide) injection 0.5 mg, 1 mg, or
2 mg is an injectable prescription medicine used:

•along with diet and exercise to improve blood
sugar (glucose) in adults with type 2 diabetes.

•to reduce the risk of major cardiovascular events
such as heart attack, stroke, or death in adults
with type 2 diabetes with known heart disease.

It is not known if Ozempic^® can be used in people who have had pancreatitis.

Ozempic^® is not for use in people with type 1 diabetes.

It is not known if Ozempic^® is safe and effective for use in children under 18 years of age.

Do not use Ozempic^® if:

•you or any of your family have ever had MTC or if
you have MEN 2.

•you are allergic to semaglutide or any of the
ingredients in Ozempic^®. See symptoms of serious
allergic reaction in "What are the possible side
effects of Ozempic^®?".

Before using Ozempic^®, tell your health care
provider if you have any other medical
conditions, including if you:

•have or have had problems with your pancreas or
kidneys.

•have a history of diabetic retinopathy.

•are pregnant or breastfeeding or plan to become
pregnant or breastfeed. It is not known if
Ozempic^® will harm your unborn baby or passes
into your breast milk. You should stop using
Ozempic^® 2 months before you plan to become
pregnant.

Tell your health care provider about all the
medicines you take, including prescription and
over-the-counter medicines, vitamins, herbal
supplements, and other medicines to treat
diabetes, including insulin or sulfonylureas.

What are the possible side effects of Ozempic^®?

Ozempic^® may cause serious side effects,
including:

•inflammation of your pancreas (pancreatitis).
Stop using Ozempic^® and call your health care
provider right away if you have severe pain in
your stomach area (abdomen) that will not go
away, with or without vomiting. You may feel the
pain from your abdomen to your back.

•changes in vision. Tell your health care provider
if you have changes in vision during treatment
with Ozempic^®.

•low blood sugar (hypoglycemia). Your risk for
getting low blood sugar may be higher if you use
Ozempic^® with another medicine that can cause
low blood sugar, such as a sulfonylurea or insulin.
Signs and symptoms of low blood sugar may
include: dizziness or lightheadedness, blurred
vision, anxiety, irritability or mood changes,
sweating, slurred speech, hunger, confusion or
drowsiness, shakiness, weakness, headache, fast
heartbeat, and feeling jittery.

•kidney problems (kidney failure). In people who
have kidney problems, diarrhea, nausea, and
vomiting may cause a loss of fluids (dehydration),
which may cause kidney problems to get worse. It
is important for you to drink fluids to help reduce
your chance of dehydration.

•serious allergic reactions. Stop using Ozempic^®
and get medical help right away if you have any
symptoms of a serious allergic reaction, including
swelling of your face, lips, tongue, or throat;
problems breathing or swallowing; severe rash or
itching; fainting or feeling dizzy; or very rapid
heartbeat.

• gallbladder problems. Gallbladder problems
have happened in some people who take
Ozempic^®. Tell your health care provider right
away if you get symptoms which may include:
pain in your upper stomach (abdomen), fever,
yellowing of the skin or eyes (jaundice), or
clay-colored stools.

The most common side effects of Ozempic^® may
include nausea, vomiting, diarrhea, stomach (abdominal) pain, and constipation.

Please see Prescribing Information and Medication Guide.

Ozempic^® is a prescription medication.

Novo Nordisk provides patient assistance for those
who qualify. Please call 1-866-310-7549 to learn
more about Novo Nordisk assistance programs.

You are encouraged to report negative side effects
of prescription drugs to the FDA. Visit
www.fda.gov/medwatch or call 1-800-FDA-1088.

Ozempic^® is a registered trademark of Novo
Nordisk A/S.

Novo Nordisk is a registered trademark of Novo
Nordisk A/S.

© 2023 Novo Nordisk
All rights reserved.
US23OZM00104
August 2023

Important Safety Information