•Possible thyroid tumors,
including cancer. Tell your
healthcare provider if you
get a lump or swelling in
your neck, hoarseness,
trouble swallowing, or
shortness of breath. These
may be symptoms of thyroid
cancer. In studies with
rodents, RYBELSUS^® and
medicines that work like
RYBELSUS^® caused thyroid
tumors, including thyroid
cancer. It is not known if
RYBELSUS^® will cause
thyroid tumors or a type of
thyroid cancer called
medullary thyroid carcinoma
(MTC) in people

•you or any of your family
have ever had MTC, or if you
have an endocrine system
condition called Multiple
Endocrine Neoplasia
syndrome type 2 (MEN 2)

•you have had a serious
allergic reaction to
semaglutide or any of the
ingredients in RYBELSUS^®.
See symptoms of serious
allergic reaction in “What
are the possible side
effects of RYBELSUS^®?”

•have or have had problems
with your pancreas or
kidneys

•have a history of vision
problems related to your
diabetes

•are pregnant or plan to
become pregnant. It is not
known if RYBELSUS^® will
harm your unborn baby. You
should stop using
RYBELSUS^® 2 months before
you plan to become
pregnant. Talk to your
healthcare provider about
the best way to control your
blood sugar if you plan to
become pregnant or while
you are pregnant

•are breastfeeding or plan to
breastfeed. Breastfeeding is
not recommended during
treatment with RYBELSUS^®

•Take RYBELSUS^® exactly as
your healthcare provider
tells you to

•Take RYBELSUS^® by mouth
on an empty stomach when
you first wake up with a sip
of plain water (no more than
4 ounces)

•Do not split, crush, or chew.
Swallow RYBELSUS^® whole

•After 30 minutes, you can
eat, drink, or take other oral
medicines

•If you miss a dose of
RYBELSUS^®, skip the missed
dose and go back to your
regular schedule

•inflammation of your
pancreas (pancreatitis).
Stop using RYBELSUS^® and
call your healthcare provider
right away if you have severe
pain in your stomach area
(abdomen) that will not go
away, with or without
vomiting. You may feel the
pain from your abdomen to
your back

•changes in vision. Tell your
healthcare provider if you
have changes in vision
during treatment with
RYBELSUS^®

•low blood sugar
(hypoglycemia). Your risk
for getting low blood sugar
may be higher if you use
RYBELSUS^® with another
medicine that can cause low
blood sugar, such as a
sulfonylurea or insulin.
Signs and symptoms of
low blood sugar may
include: dizziness or
lightheadedness, blurred
vision, anxiety, irritability or
mood changes, sweating,
slurred speech, hunger,
confusion or drowsiness,
shakiness, weakness,
headache, fast heartbeat,
and feeling jittery

•kidney problems (kidney
failure). In people who have
kidney problems, diarrhea,
nausea, and vomiting may
cause a loss of fluids
(dehydration), which may
cause kidney problems to
get worse. It is important for
you to drink fluids to help
reduce your chance of
dehydration

•serious allergic reactions.
Stop using RYBELSUS^® and
get medical help right away,
if you have any symptoms of
a serious allergic reaction,
including swelling of your
face, lips, tongue, or throat;
problems breathing or
swallowing; severe rash or
itching; fainting or feeling
dizzy; or very rapid
heartbeat

•RYBELSUS^® is not
recommended as the first
choice of medicine for
treating diabetes

•It is not known if RYBELSUS^®
can be used in people who
have had pancreatitis

•RYBELSUS^® is not for use in
people with type 1 diabetes

•It is not known if RYBELSUS^®
is safe and effective for use
in children under 18 years of
age