For adults with type 2 diabetes, along with
diet and exercise, to improve blood sugar
Actor portrayal
RYBELSUS® can help
get your A1C DOWN.
See study results
What is the most important information I should know about RYBELSUS®?
RYBELSUS® may cause serious side effects, including:
•
Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, RYBELSUS® and medicines that work like RYBELSUS® caused thyroid tumors, including thyroid cancer. It is not known if RYBELSUS® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people
Do not use RYBELSUS® if:
•
you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
•
you have had a serious allergic reaction to semaglutide or any of the ingredients in RYBELSUS®. See symptoms of serious allergic reaction in “What are the possible side effects of RYBELSUS®?”
What is RYBELSUS®?
RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is a prescription medicine used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes.
•
It is not known if RYBELSUS® can be used in people who have had pancreatitis
•
RYBELSUS® is not for use in people with type 1 diabetes
•
It is not known if RYBELSUS® is safe and effective for use in children under 18 years of age
Important Safety Information
Before using RYBELSUS®, tell your healthcare provider if you have any other medical conditions, including if you:
•
have or have had problems with your pancreas or kidneys
•
have a history of vision problems related to your diabetes
•
are pregnant or plan to become pregnant. It is not known if RYBELSUS® will harm your unborn baby. You should stop using RYBELSUS® 2 months before you plan to become pregnant. Talk to your healthcare provider about the best way to control your blood sugar if you plan to become pregnant or while you are pregnant
•
are breastfeeding or plan to breastfeed. Breastfeeding is not recommended during treatment with RYBELSUS®
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. RYBELSUS® may affect the way some medicines work and some medicines may affect the way RYBELSUS® works.
What are the possible side effects of RYBELSUS®?
RYBELSUS® may cause serious side effects, including:
•
inflammation of your pancreas (pancreatitis). Stop using RYBELSUS® and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back
•
changes in vision. Tell your healthcare provider if you have changes in vision during treatment with RYBELSUS®
•
low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use RYBELSUS® with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include: dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery
•
kidney problems (kidney failure). In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse. It is important for you to drink fluids to help reduce your chance of dehydration
•
serious allergic reactions. Stop using RYBELSUS® and get medical help right away, if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat
•
gallbladder problems. Gallbladder problems have happened in some people who take RYBELSUS®. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include: pain in your upper stomach (abdomen), yellowing of skin or eyes (jaundice), fever, and clay-colored stools
The most common side effects of RYBELSUS® may include nausea, stomach (abdominal) pain, diarrhea, decreased appetite, vomiting, and constipation. Nausea, vomiting, and diarrhea are most common when you first start RYBELSUS®.
Please see Prescribing Information and Medication Guide.
RYBELSUS® is a prescription medication.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
RYBELSUS® is a registered trademark of Novo
Nordisk A/S.
Novo Nordisk is a registered trademark of Novo
Nordisk A/S.
All other trademarks, registered or unregistered, are the property of their respective owners.
© 2023 Novo Nordisk
All rights reserved.
US22RYB01083April 2023
Important Safety Information
Please click here for Prescribing Information.
In a 6-month study, RYBELSUS®
lowered blood sugar better
than a leading branded pill.a
Adults with an average starting A1C of
8.3% lowered their A1C by an average of:
• -1.0% on 7 mg of RYBELSUS®
 • -1.3% on 14 mg of RYBELSUS®
 • -0.8% on 100 mg of JANUVIA®
aResults are from a 6-month medical study in 1864 adults
 with type 2 diabetes that compared RYBELSUS® with
 JANUVIA® when both were added to 1 or 2 diabetes pills.
In the same study, people
taking RYBELSUS® 14 mg
lost 5x more weight.b
People who weighed an average of
200 pounds, on average, lost around:
• 4.8 pounds on 7 mg of RYBELSUS®
 • 6.8 pounds on 14 mg of RYBELSUS®
 • 1.3 pounds on 100 mg of JANUVIA®
 RYBELSUS® is not a weight-loss drug.
Once-daily RYBELSUS®
lowers A1C and may help
you lose some weight.b
RYBELSUS® is not a weight-loss drug.
bWhile many people in medical studies lost weight,
  some did gain weight. Individual results may vary.
For adults with type 2 diabetes, along with
diet and exercise, to improve blood sugar
Actor portrayal
Learn more
What is the most important information I should know about RYBELSUS®?
RYBELSUS® may cause serious side effects, including:
•
Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, RYBELSUS® and medicines that work like RYBELSUS® caused thyroid tumors, including thyroid cancer. It is not known if RYBELSUS® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people
Do not use RYBELSUS® if:
•
you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
•
you have had a serious allergic reaction to semaglutide or any of the ingredients in RYBELSUS®. See symptoms of serious allergic reaction in “What are the possible side effects of RYBELSUS®?”
What is RYBELSUS®?
RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is a prescription medicine used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes.
•
It is not known if RYBELSUS® can be used in people who have had pancreatitis
•
RYBELSUS® is not for use in people with type 1 diabetes
•
It is not known if RYBELSUS® is safe and effective for use in children under 18 years of age
Important Safety Information
Before using RYBELSUS®, tell your healthcare provider if you have any other medical conditions, including if you:
•
have or have had problems with your pancreas or kidneys
•
have a history of vision problems related to your diabetes
•
are pregnant or plan to become pregnant. It is not known if RYBELSUS® will harm your unborn baby. You should stop using RYBELSUS® 2 months before you plan to become pregnant. Talk to your healthcare provider about the best way to control your blood sugar if you plan to become pregnant or while you are pregnant
•
are breastfeeding or plan to breastfeed. Breastfeeding is not recommended during treatment with RYBELSUS®
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. RYBELSUS® may affect the way some medicines work and some medicines may affect the way RYBELSUS® works.
What are the possible side effects of RYBELSUS®?
RYBELSUS® may cause serious side effects, including:
•
inflammation of your pancreas (pancreatitis). Stop using RYBELSUS® and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back
•
changes in vision. Tell your healthcare provider if you have changes in vision during treatment with RYBELSUS®
•
low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use RYBELSUS® with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include: dizziness or lightheadedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling jittery
•
kidney problems (kidney failure). In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse. It is important for you to drink fluids to help reduce your chance of dehydration
•
serious allergic reactions. Stop using RYBELSUS® and get medical help right away, if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat
•
gallbladder problems. Gallbladder problems have happened in some people who take RYBELSUS®. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include: pain in your upper stomach (abdomen), yellowing of skin or eyes (jaundice), fever, and clay-colored stools
The most common side effects of RYBELSUS® may include nausea, stomach (abdominal) pain, diarrhea, decreased appetite, vomiting, and constipation. Nausea, vomiting, and diarrhea are most common when you first start RYBELSUS®.
Please see Prescribing Information and Medication Guide.
RYBELSUS® is a prescription medication.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
RYBELSUS® is a registered trademark of Novo
Nordisk A/S.
Novo Nordisk is a registered trademark of Novo
Nordisk A/S.
All other trademarks, registered or unregistered, are the property of their respective owners.
© 2023 Novo Nordisk
All rights reserved.
US22RYB01083April 2023
Important Safety Information
Please click here for Prescribing Information.
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