br.not-default {
  display: none;
}

.text-center {
  text-align: center;
}
#clickScreen { z-index:3; } 
#container_ad,
#container_anim,
#chromeCover,
#clickScreen {
  position: absolute;
  width: 160px;
  height: 600px;
}

.reference-wrap .with-ref, .footnote-wrap .with-ref {
  padding-left: 4px;
  position: relative;
}
.reference-wrap .with-ref sup:first-of-type, .footnote-wrap .with-ref sup:first-of-type {
  position: absolute;
  left: 0;
  top: 3px;
}
html,
body,
* {
  padding: 0;
  margin: 0;
}

#container_ad {
  overflow: hidden;
  border: 1px solid #B5B5B5;
  box-sizing: border-box;
}

#container_anim {
  left: -1px;
  top: -1px;
}
#container_anim * { user-select: none; }

#chromeCover {
  background-color: #ffffff;
}

.fontSize-11 {
  font-size: 11px !important;
}

.fontSize-14 {
  font-size: 14px !important;
}

.fontSize-15 {
  font-size: 15px !important;
}

.fontWeight-bold {
  font-weight: 700 !important;
}

.color-purple {
  color: #61279e;
}

sup,
sub {
  line-height: 0px;
}

h1,
h2,
h3 {
  font-family: "Open Sans";
  color: #fff;
  font-weight: 600;
}
h1.medium,
h2.medium,
h3.medium {
  font-weight: 400;
}

h1 {
  font-weight: 700;
}
h1.medium {
  font-weight: 400;
}

sup {
  font-size: 50%;
}

.ref {
  margin-left: 5px;
}
.ref sup:first-of-type {
  margin-left: -5px;
}
@charset "UTF-8";
#logo-servier-isi {
  width: 100%;
  max-width: 160px;
  height: auto;
  display: block;
  margin: 16px auto 12px;
}

.sectionBorder {
  border: 1.5px solid #636466;
  padding: 7px;
}

.listItem-bull {
  margin-left: 12px;
}
.listItem-bull::before {
  content: "•";
  margin-right: 4px;
  margin-left: -8px;
  font-size: 12px;
  line-height: 11px;
}

.iScrollLoneScrollbar {
  width: 4px;
  overflow: initial !important;
  background-color: #565757;
  border-radius: 5px;
  border-bottom: 3px solid #565757;
}

.iScrollVerticalScrollbar .iScrollIndicator {
  width: 2px;
  background-color: #ffffff;
  border-radius: 5px;
  left: 1px;
  top: 1px;
}

#containerISI,
#isiContent,
#isiPiBottom,
.iScrollVerticalScrollbar,
.iScrollIndicator {
  position: absolute;
}

.iScrollVerticalScrollbar {
  bottom: 22px;
  top: 8px;
  right: 8px;
}

#isiContent {
  background-color: #ffffff;
  overflow: hidden;
  height: 100%;
  width: 100%;
}
#isiContent p {
  font-size: 12px;
}

#containerISI {
  bottom: 0;
  font-family: "Barlow Semi Condensed", sans-serif;
  color: #636466;
  font-size: 12px;
  width: 100%;
  height: undefined0px;
}

#scroller {
  width: 95%;
  width: calc(100% - 30px);
  padding: 5px 5px 16px 5px;
}
#scroller p {
  margin-bottom: 6px;
}
#scroller p.isiHeading {
  padding-top: 6px;
}
#scroller .long-url {
  word-break: break-word;
}
#scroller .footnote-wrap,
#scroller .reference-wrap {
  padding-top: 6px;
  margin-bottom: 0;
}
#scroller .footnote-wrap p,
#scroller .reference-wrap p {
  margin-top: 0;
  margin-bottom: 0;
}
#scroller .footnote-wrap {
  margin-bottom: 6px;
}
#scroller .endMatter {
  margin-top: 6px;
  margin-bottom: 0;
}
#scroller .endMatter:last-of-type {
  padding-bottom: 6px;
}

#isiPiBottom {
  background-color: #565757;
  text-align: left;
  width: 100%;
  bottom: 0;
  display: inline-block;
  padding-right: 3px;
  padding-left: 5px;
  padding-top: 1px;
  height: 16px;
  font-size: 12px;
  line-height: 13px;
  color: #ffffff !important;
}
#isiPiBottom a {
  padding-bottom: 3px;
  padding-top: 3px;
  color: #ffffff !important;
}
#isiPiBottom span {
  font-size: 11px;
}
#bg_img img {
  width: 100%;
  height: 100%;
  max-width: 100%;
  max-height: 100%;
  z-index: 1;
}
#bg_img img.bone {
  position: absolute;
  top: 0;
  left: 0;
}
#bg_img #gradient {
  background: rgb(13, 62, 53);
  background: -moz-linear-gradient(0deg, rgba(0, 89, 72, 0.80) 0%, rgba(2, 85, 69, 0) 25%, rgba(7, 74, 62, 0) 50%, rgba(13, 62, 53, 0.85) 100%);
  background: -webkit-linear-gradient(0deg, rgba(0, 89, 72, 0.80) 0%, rgba(2, 85, 69, 0) 25%, rgba(7, 74, 62, 0) 50%, rgba(13, 62, 53, 0.85) 100%);
  background: linear-gradient(0deg, rgba(0, 89, 72, 0.80) 0%, rgba(2, 85, 69, 0) 25%, rgba(7, 74, 62, 0) 50%, rgba(13, 62, 53, 0.85) 100%);
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr="#0d3e35",endColorstr="#0d3e35",GradientType=1);
  position: absolute;
  height: 100%;
  width: 100%;
  opacity: 0;
  z-index: 2;
}

body {
  font-family: "Open Sans", Arial, sans-serif;
}

h1, h2, p, span {
  color: #fff;
}

h1 {
  font-size: 28px;
  font-weight: 800;
  line-height: 30px;
}
h1.small {
  font-size: 25px;
  font-weight: 600;
}

h2 {
  font-size: 25px;
  line-height: 28px;
  font-weight: 500;
}
h2 strong {
  font-weight: 800;
}

h1, h2 {
  text-shadow: 1px 3px 2px rgba(0, 0, 0, 0.5);
}

span {
  font-size: 9px;
  line-height: 11px;
  display: block;
  font-weight: 400;
}

#mds_logo {
  position: absolute;
  top: 1px;
  right: 13px;
  opacity: 0;
  z-index: 3;
  box-shadow: 0px 3px 6px rgba(0,0,0,0.16);
}

#text01_1, #text01_2, #text01_3, #text02_1, #text02_2, #text02_3 {
  position: absolute;
  top: 0;
  left: 0;
  opacity: 0;
  width: 100%;
  z-index: 3;
}
#text01_1 h1, #text01_1 h2, #text01_1 span, #text01_2 h1, #text01_2 h2, #text01_2 span, #text01_3 h1, #text01_3 h2, #text01_3 span, #text02_1 h1, #text02_1 h2, #text02_1 span, #text02_2 h1, #text02_2 h2, #text02_2 span, #text02_3 h1, #text02_3 h2, #text02_3 span {
  padding-left: 13px;
  padding-right: 13px;
}

#text01_1, #text02_1, #cta {
  left: -100%;
}

#cta {
  display: block;
  position: absolute;
  z-index: 3;
  left: 13px;
  transform: translate(-100%, 0);
  top: 163px;
  opacity: 0;
  border-radius: 20px;
  background-color: #0074A8;
  text-decoration: none;
  width: 121px;
  height: 33px;
  box-sizing: border-box;
  border: 2px solid #fff;
}
#cta span {
  font-family: "Open Sans", sans-serif;
  font-weight: 700;
  color: #fff;
  text-align: left;
  position: relative;
  left: 20px;
  top: 3px;
  font-size: 12px;
  line-height: 22px;
  letter-spacing: -0.02em;
}
#cta img {
  position: absolute;
  right: 17px;
  top: 9px;
  width: 6px;
  height: 10px;
}

#mds_logo {
  width: 126px;
  height: 58px;
}

#text01_1 {
  top: 42px;
}
#text01_1 br.not-default {
  display: block;
}
#text01_2 {
  top: 231px;
}

#text01_2 span, #text02_2 span {
  font-size: 9px;
  line-height: 9px;
}
#text01_3 span, #text02_3 span {
  font-size: 9px;
  line-height: 9.5px;
}
.banner-160x600 #bg_img #gradient {
  background: rgb(13, 62, 53);
  background: -moz-linear-gradient(0deg, rgba(13, 62, 53, 0.85) 0%, rgba(8, 72, 60, 0.16) 25%, rgba(2, 85, 69, 0) 75%, rgba(0, 89, 72, 0.85) 100%);
  background: -webkit-linear-gradient(0deg, rgba(13, 62, 53, 0.85) 0%, rgba(8, 72, 60, 0.16) 25%, rgba(2, 85, 69, 0) 75%, rgba(0, 89, 72, 0.85) 100%);
  background: linear-gradient(0deg, rgba(13, 62, 53, 0.85) 0%, rgba(8, 72, 60, 0.16) 25%, rgba(2, 85, 69, 0) 75%, rgba(0, 89, 72, 0.85) 100%);
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr="#0d3e35",endColorstr="#005948",GradientType=1);
}
.banner-160x600 #bone {
  background-image: url("../images/bones.png");
  height: 100%;
  width: 100%;
  position: absolute;
  top: 0;
  left: 0;
  background-repeat: no-repeat;
  background-position: left;
  background-size: 300px;
}
.banner-160x600 h1 {
  font-size: 25px;
  font-weight: 800;
  line-height: 26px;
}
.banner-160x600 h1.small {
  font-size: 22px;
  line-height: 26px;
  font-weight: 600;
}
.banner-160x600 h2 {
  font-size: 22px;
  line-height: 24px;
  font-weight: 500;
}
.banner-160x600 h2 strong {
  font-weight: 800;
}
.banner-160x600 #text01_1 {
  top: 78px;
}
.banner-160x600 #text01_1 h1 {
  padding-left: 7px;
}
.banner-160x600 #text01_2 {
  top: unset;
  bottom: 6px;
}
.banner-160x600 #text01_2 span {
  padding-left: 4px;
}
.banner-160x600 #text02_1 {
  top: 78px;
}
.banner-160x600 #text02_1 h2 {
  padding-left: 7px;
}
.banner-160x600 #text02_2 {
  top: unset;
  bottom: 48px;
}
.banner-160x600 #text02_2 span {
  padding-left: 4px;
}
.banner-160x600 #text02_3 {
  top: unset;
  bottom: 5px;
}
.banner-160x600 #text02_3 span {
  padding-left: 4px;
}
.banner-160x600 #cta {
  top: 212px;
  left: 20px;
}