Frequently Asked Questions - CAPLYTA® (lumateperone) Skip to Main Content For US Residents Only Visit US Healthcare Professionals Site Important Safety Information Important Safety Information Prescribing Information Medication Guide Other Indications Cost & Savings Menu About Schizophrenia About Caplyta Common Side Effects Taking Caplyta Support & Resources Talking to a healthcare provider Patient & caregiver support Frequently asked questions Cost & Savings About Schizophrenia About Caplyta Common Side Effects Taking Caplyta Support & Resources Talking to a healthcare provider Patient & caregiver support Frequently asked questions Learn about speaking with a healthcare provider For US Residents Only Other Indications Visit US Healthcare Professionals Website Frequently asked questions Find answers to your questions about CAPLYTA Actor portrayals. From how it works to how often to take it, explore the FAQs below to learn all about CAPLYTA. About CAPLYTA Expand all collapse How is CAPLYTA pronounced? cap-LITE-uh collapse What is CAPLYTA used for? CAPLYTA is a prescription medicine used to treat adults with schizophrenia. Learn more about who CAPLYTA may help collapse How does CAPLYTA work? Although the exact way CAPLYTA works is unknown, it is thought to affect different brain‑signaling chemicals to help control schizophrenia symptoms. Learn more about how CAPLYTA works Common side effects Expand all collapse Does CAPLYTA cause weight gain? Weight change on CAPLYTA was similar to placebo in short-term trials. In a long-term study, patients on CAPLYTA for one year had an average weight loss of 7 pounds. CAPLYTA, like other drugs used to treat schizophrenia, may cause problems with your metabolism, including high blood sugar, diabetes, increased fat (cholesterol and triglyceride) levels in your blood, and weight gain. Your doctor should check your blood sugar, fat levels, and weight before you start and during your treatment with CAPLYTA. Extremely high blood sugar levels can lead to coma or death. Tell your doctor if you have symptoms of high blood sugar, which include feeling very thirsty, hungry, sick to your stomach, weak/tired, or needing to urinate more than usual. Each drug has its own specific risk profile. Learn more collapse Does CAPLYTA make you tired? The most common side effects with CAPLYTA are sleepiness (24%) and dry mouth (6%). In clinical trials, sleepiness was predominantly mild. Follow your healthcare provider's direction on when and how to take CAPLYTA. CAPLYTA can cause sleepiness and trouble concentrating. Until you know how CAPLYTA affects you, do not drive, operate heavy machinery, or do other dangerous activities. Learn more How to take CAPLYTA Expand all collapse How do you take CAPLYTA? CAPLYTA is a once-daily pill to be taken with or without food. Learn more collapse When should CAPLYTA be taken? Your healthcare provider may tell you what time of day or night is best for you to take CAPLYTA. CAPLYTA can cause sleepiness and trouble concentrating. Until you know how CAPLYTA affects you, do not drive, operate heavy machinery, or do other dangerous activities. Learn more Learn about the CAPLYTA Savings Card About CAPLYTA Learn more about how CAPLYTA may help About schizophrenia Learn about the disease and what it means for you Terms of Use Privacy Policy Cookie Policy Contact Us ITCI Corporate Site Sitemap Your Privacy Choices AdChoices Opt-Out © Johnson & Johnson and its affiliates 2025. CAPLYTA and LET IN THE LYTE are trademarks of Johnson & Johnson and its affiliates. Trademarks listed are the property of their respective owners. 11/25 US-CAP-2500313