Common Side Effects of CAPLYTA® (lumateperone) Skip to Main Content For US Residents Only Visit US Healthcare Professionals Site Important Safety Information Important Safety Information Prescribing Information Medication Guide Other Indications Cost & Savings Menu About Schizophrenia About Caplyta Common Side Effects Taking Caplyta Support & Resources Talking to a healthcare provider Patient & caregiver support Frequently asked questions Cost & Savings About Schizophrenia About Caplyta Common Side Effects Taking Caplyta Support & Resources Talking to a healthcare provider Patient & caregiver support Frequently asked questions Learn about speaking with a healthcare provider For US Residents Only Other Indications Visit US Healthcare Professionals Website Common Side Effects We understand that side effects might be a concern when thinking about starting a new medicine Actor portrayal. In 2 clinical trials, CAPLYTA was proven to help control symptoms of schizophrenia with demonstrated safety. Side effects of CAPLYTA The most common side effects experienced by people taking CAPLYTA were sleepiness, dizziness, nausea, dry mouth, feeling tired, and diarrhea. CAPLYTA can cause sleepiness and trouble concentrating. Until you know how CAPLYTA affects you, do not drive, operate heavy machinery, or do other dangerous activities. In clinical trials, sleepiness was predominantly mild. Your healthcare provider may tell you what time of day or evening is best for you to take CAPLYTA. Follow your healthcare provider’s direction on when and how to take CAPLYTA. Do blood glucose, cholesterol, or triglycerides go up on CAPLYTA? In clinical trials, changes in blood glucose, cholesterol, and triglycerides in patients taking CAPLYTA were similar to those in patients taking a sugar pill. What about weight change? In a long-term study, patients on CAPLYTA for one year had an average weight loss of 7 pounds. CAPLYTA, like other drugs used to treat schizophrenia, may cause problems with your metabolism, including high blood sugar, diabetes, increased fat (cholesterol and triglyceride) levels in your blood, and weight gain. Your doctor should check your blood sugar, fat levels, and weight before you start and during your treatment with CAPLYTA. Extremely high blood sugar levels can lead to coma or death. Tell your doctor if you have symptoms of high blood sugar, which include feeling very thirsty, hungry, sick to your stomach, weak/tired, or needing to urinate more than usual. Each drug has its own specific risk profile. Do patients on CAPLYTA experience movement disorders? In clinical trials, movement disorders were uncommon and similar to sugar pill. 6.7% of patients taking CAPLYTA vs. 6.3% of patients taking a sugar pill Like other schizophrenia medications, CAPLYTA may cause movements that you cannot control in your face, tongue, or other body parts. This can be a sign of tardive dyskinesia. Tardive dyskinesia is a movement disorder that may not go away, even if you stop taking CAPLYTA. Tardive dyskinesia may also start after you stop taking CAPLYTA. CAPLYTA® (lumateperone) savings card Savings Offer & Cost* Explore ways you might save on CAPLYTA Once daily Taking CAPLYTA Learn about getting started with CAPLYTA *Please see Eligibility Requirements and Terms & Conditions Terms of Use Privacy Policy Cookie Policy Contact Us ITCI Corporate Site Sitemap Your Privacy Choices AdChoices Opt-Out © Johnson & Johnson and its affiliates 2025. CAPLYTA and LET IN THE LYTE are trademarks of Johnson & Johnson and its affiliates. Trademarks listed are the property of their respective owners. 11/25 US-CAP-2500313